FcγRIIa defunctioning polymorphism in paediatric patients with renal allograft

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FcγRIIa defunctioning polymorphism in paediatric patients with renal allograft

Introduction Fc gamma receptor (FcγR) IIa is considered the most widely distributed of the three classes of Fc receptors, and it expresses an allelic polymorphism. This type of polymorphism may modify the immune response and may be an important factor for some diseases. The aim of the study reported herein was to evaluate the association between the FcγRIIa polymorphism and susceptibility to bo...

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STAT4 gene polymorphism in patients after renal allograft transplantation

INTRODUCTION STAT4 (signal transducer and activator of transcription 4) is involved in the regulation of innate and adaptive immune responses. Some studies have suggested that STAT4 may be involved in the immune response after graft transplantation. Several polymorphisms in the STAT4 gene have been identified. The most commonly studied polymorphism in the STAT4 gene is rs7574865. In our study, ...

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Renalase gene polymorphism in patients after renal allograft transplantation.

BACKGROUND/AIMS Renalase is a recently discovered protein, which is likely involved in regulation of blood pressure in humans and animals. Previous studies suggest that renalase reflects kidney functioning. A common missense polymorphism in the flavin-adenine dinucleotide-binding domain of human renalase (Glu37Asp) has been described. In this study we examined the association between (Glu37Asp)...

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Association of FCγRIIA (CD32) polymorphism with susceptibility to brucellosis

Background: Brucellosis is the major bacterial zoonoses of global importance caused by Brucella spps. FCγRIIA receptor plays a central role in phagocytosis of IgG2-opsonized bacteria. FCγRIIA exhibits allelic polymorphisms with different capacities for binding IgG2 and phagocytosis. Cells expressing Fc γ RIIa-H131, bind more efficiently to complexes of IgG2 than those expressi...

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ژورنال

عنوان ژورنال: Central European Journal of Immunology

سال: 2017

ISSN: 1426-3912

DOI: 10.5114/ceji.2017.72817